Biography:

David W. Li received his Ph.D. degree in molecular and cellular biology from the University of Washington in Seattle, and completed his postdoctoral training in the Harkness Eye Institute of Columbia Medical Center in New York City. He is currently an elected One-Hundred Talent Professor in the State Key Laboratory of Zhongshan Ophthalmic Center in Sun Yat-sen University

Abstract:

The tumor suppressor p53 plays an essential role in mediating lens differentiation and heterochromatin protection of RPE cells The tumor suppressor, p53 is a multi-function molecule regulating transcription, cell proliferation, differentiation and apoptosis. However, how would p53 regulate lens differentiation remains largely known until our recent demonstration. Oxidative stress (OS)-induced retinal pigment epithelium (RPE) cell apoptosis is critically implicated in the pathogenesis of age-related macular degeneration (AMD), one of the leading causes for blindness in the elderly. The highly condensed, repressive heterochromatin is recently found to play critical roles in mediating diverse stress response. How RPE heterochromatin is regulated upon OS exposure is largely unknown. Here in this lecture, I will discuss our recent work using both mouse model and cultured human RPE cells to investigate how p53 mediates the heterochromatin protection of RPE cells against oxidative damage upon OS exposure.

Biography:

Abstract:

Biography:

Ophthalmology in various meetings

Abstract:

cardioembolic source or giant cell arteritis, until proven otherwise

Biography:

More than thousands of Vitreo-Retinal and Cataract surgeries of all complexities. • Hundreds of tube-shunt implantations for Glaucoma, Corneal transplantations and Refractive surgeries. Member of American Society of Retina Specialists ASRS Member of European Society of Cataract & Refractive Surgeons (ESCRS)

Abstract:

Purpose: To compare and evaluate anatomical and functional outcomes of two different surgical techniques to treat hemorrhagic AMD. Methods: The method involved prospective interventional case series. Twelve eyes of 12 patients having subfoveal hemorrhage secondary to wet-AMD were enrolled and divided in two groups. Group 1 includes eight eyes of 8 patients, where PPV was performed. Using 41 Gauge subretinal cannula BSS diluted with tPA (125 mg/ml) was injected to detach the macula. After fluid-air exchange, non-expansile gas was used to fill up only 50% of the vitreous cavity. Group 2 includes four eyes of 4 patients. After PPV peripheral, temporal 200° retinotomy was performed, retina was detached, and free flap was inverted, subfoveal hemorrhage was removed via direct approach and conventional silicone oil tamponade was used. Cases were followed up for 12 months. Results: In Group 1 submacular hemorrhage was successfully displaced inferiorly within 3 days and then completely reabsorbed after few weeks in all 8 cases. The mean VA improved from baseline 0.01 decimals (varied from HM to 0.02) to 0.2 decimals (varied from 0.09 to 0.7) at 12 months. In Group 2 submacular hemorrhage was completely removed in all cases, but mean VA at 12 months was not as high as in Group 1, where mean preoperative VA was 0.01 decimals (varied from HM to 0.03) and mean postoperative VA was 0.05 (varied from HM to 0.1), respectively. No recurrent subfoveal hemorrhage was observed in any group. Subfoveal fibrosis was progressed in 2 out of 8 eyes in Group 1 and 2 out of 4 eyes in Group 2. Significant Optic Nerve atrophy was observed in Group 1 in all cases. This latest can be the main reason why we couldn’t achieve significant improvement of VA in Group 2. Conclusions: This study shows that the technique used in Group one is superior than the technique used in group 2. Thus, minimally invasive procedure should be considered to treat cases of wet AMD complicated with subfoveal hemorrhage.

Biography:

Dr. Jose Bonifacio Barbosa Jr is currently working as an Ophthalmology Consultant in UDI Hospital, Sao Paulo, Brazil. His research interests include Cornea, Refractive Surgery and Ocular external diseases etc . He is serving as an editorial member and reviewer in several international reputed journals. Dr. Jose Bonifacio Barbosa Jr is also a member of many international affiliations. He has authored many research articles/books related to his Research interest.

Abstract:

Introduction: To compare amniotic membrane transplantation (AMT) associated with narrow-strip conjunctival autograft versus conjunctival autograft alone for the treatment of recurrent pterygium. Methods & Patients: Prospective consecutive interventional study was performed. Patients with recurrent pterygium were randomly divided into one of two groups; group 1: patients undergoing AMT associated with autologous conjunctival graft, and group 2: patients undergoing conjunctival autograft alone. Results: Of the 80 operated eyes included in this study, 39 (Group 1, mean patient age: 52.1±11.7 SD years) underwent AMT associated with narrow-strip conjunctival autograft and 41 (Group 2, mean patient age: 45.8±12.9 SD years) underwent conjunctival autograft alone. In Group 1, 6 eyes (15.4%) had grade-1 pterygium, 19 eyes (48.7%) had grade-2 pterygium, and 14 eyes (35.9%) had grade-3 pterygium. In the second group, 5 eyes (12.2%) had grade-1 pterygium, 18 eyes (43.9%) had grade-2 pterygium, and 14 eyes (35.9%) had grade-3 pterygium. No statistically significant difference was found between the two groups (P=0.752). Of the 39 eyes in Group 1, recurrent pterygium was observed in 7 cases (17.9%). However, of the 41 eyes in Group 2, recurrent pterygium was observed in only 4 cases (9.75%). No statistically significant difference was found between the two groups (P=0.2684). Conclusions: The results of this study indicate that conjunctival autograft alone might be a better surgical choice for the treatment of recurrent pterygia than combining it with AMT, however, this second option provides a good surgical alternative in cases where little conjunctival donor tissue is available. Recent Publications 1. Taylan Sekeroglu H, Erdem E, Dogan N C, Yagmur M, Ersoz R, Dogan A (2011) Sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft for pterygium. Int. Ophthalmol. 31(6):433-438. 2. Hirst LW (2009) Recurrent pterygium surgery using pterygium extended removal followed by extended conjunctival transplant: recurrence rate and cosmesis. Ophthalmology. 116(7):1278-1286. 3. Hovanesian J A, Starr C E, Vroman D T, Mah F S, Gomes J A P et. al (2017) Surgical techniques and adjuvants for the management of primary and recurrent pterygia. J. Cataract Refract. Surg. 43(3):405-419. 4. Barbosa Jr. J B, Farias, C C, Hirai F E, Pereira Gomes J A (2017) Amniotic membrane transplantation with narrow strip conjunctival autograft vs. conjunctival autograft for recurrent pterygia. Eur. J. Ophthalmol. 27(2):135-140. 5. Solomon A, Pires R T, Tseng S C (2001) Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia. Ophthalmology. 108(3):449-460